Ayala rose to fame in the 1960s as a member of the musical group Los Relámpagos del Norte before launching a successful solo career. He is known for his accordion playing skills and his ability to capture the essence of traditional Mexican music in his songs. Some of his popular songs include "Un Rinconcito en el Cielo," "Tragos Amargos," and "Chaparra de Mi Amor."

Over the years, Ramon Ayala has released numerous successful albums and singles, earning him a dedicated fan base and critical acclaim. He is considered one of the most influential figures in Norteño music, known for his unique style and his ability to connect with audiences through his music.