Kodjoe's notable roles include his portrayal of Damon Carter in the TV series "Soul Food" (2000–2004) and his participation in various films such as "Love & Basketball" (2000), "Brown Sugar" (2002), and "Madea's Family Reunion" (2006). He has showcased his talent in both drama and romantic comedy genres.

In addition to his acting career, Boris Kodjoe is known for his philanthropic efforts and advocacy work. He, along with his wife, actress Nicole Ari Parker, has been involved in initiatives related to health and wellness. The couple has spoken openly about their personal experiences, including dealing with health challenges, and has been advocates for various causes.